<?xml version="1.0" encoding="UTF-8"?>
<article article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Czech and Slovak Ophthalmology</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">334</article-id>
      <article-id pub-id-type="doi">10.31348/2024/30</article-id>
      <article-categories>
        <subj-group>
          <subject>Case report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Leiomyoma – Ciliary Body Tumor. A Case Report</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Černá</surname>
            <given-names>Karolína</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-7234-0896</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Hlinomazová</surname>
            <given-names>Zuzana</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-4037-2208</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Glezgová</surname>
            <given-names>Johana</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0284-043X</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ambrosová</surname>
            <given-names>Kateřina</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-0103-4236</contrib-id>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>25</day>
        <month>6</month>
        <year>2024</year>
      </pub-date>
      <issue>5</issue>
      <elocation-id>6</elocation-id>
      <abstract>
        <p>Aim: To demonstrate a rare case of ciliary body leiomyoma in our patient Case report: A 72-year-old female reported to our clinic for a preventive examination, upon which we found a dome-shaped grey-brownish mass on the retinal periphery. After completing gonioscopic and ultrasound examinations, we referred the patient to a specialist facility. Due to a finding of suspicious malignant melanoma, we completed the MRI scan and recommended enucleation of the eyeball. A histopathological examination showed a leiomyoma of the ciliary body. Conclusion: The aim of this case report is to demonstrate the difficulty of intraocular leiomyoma diagnosis. Only immunohistochemical examination differentiated the tumor from malignant melanoma and determined the diagnosis of ciliary body leiomyoma. Perhaps because of the extreme rarity of this type of tumor, we often neglect to consider a diagnosis of leiomyoma.</p>
      </abstract>
      <kwd-group>
        <kwd>leiomyoma</kwd>
        <kwd>ciliary body</kwd>
        <kwd>melanoma</kwd>
        <kwd>intraocular tumor</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
      <title>References</title>
      <ref id="R2422">
        <mixed-citation>Tomar AS, Finger PT, Iacob CE. Intraocular leiomyoma: Current concepts. Surv Ophthalmol. 2020 Jul;65(4):421-437.</mixed-citation>
      </ref>
      <ref id="R2423">
        <mixed-citation>Sadda SR, Wilkinson CP, Wiedemann P, Schachat AP, editors. Ryan’s Retina. Volume 3/ editor-in-chief SriniVas R. Sadda, MD (Professor of Ophthalmology, Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA). Sixth edition. London New York Oxford Philadelphia St Louis Sydney: Elsevier;2018. 1821 p.</mixed-citation>
      </ref>
      <ref id="R2424">
        <mixed-citation>Shields C, Shields J, Remmer M, Kaliki S, Eagle R. Giant leiomyoma of the ciliary body. Oman J Ophthalmol. 2014;7(2):81.</mixed-citation>
      </ref>
      <ref id="R2425">
        <mixed-citation>Biswas J, Kumar SK, Gopal L, Bhende MP. Leiomyoma of the Ciliary Body Extending to Anterior Chamber. Surv Ophthalmol. 2000 Jan;44(4):336-342.</mixed-citation>
      </ref>
      <ref id="R2426">
        <mixed-citation>Plesníková P, Jurenová D, Lysková D, Furdová A, Valášková J, Babál P. Ciliary Body Leiomyoma. Case Rep Ophthalmol. 2022 April 5;13(1):259-264.</mixed-citation>
      </ref>
      <ref id="R2427">
        <mixed-citation>Kim JM, Hall LB, Elia M, Ehrlich MS, Materin MA, Sinard JH. Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body. Ocul Oncol Pathol. 2017;3(4):304-309.</mixed-citation>
      </ref>
      <ref id="R2428">
        <mixed-citation>Fernandez de Castro JP, Syed NA. Clinicopathologic Correlation: Ciliary Body Leiomyoma. EyeRounds.org. Sept. 9, 2009; Available from: http://webeye.ophth.uiowa.edu/eyeforum/cases/ 64-Leiomyoma-Clinicopathologic.htm</mixed-citation>
      </ref>
      <ref id="R2429">
        <mixed-citation>Tomar AS, Fam A, Finger PT, Iacob CE. Doppelgänger dilemna: Leiomyoma versus uveal melanoma. AM J Ophthalmol Case Rep. 2021 Jun;22:101040.</mixed-citation>
      </ref>
      <ref id="R2430">
        <mixed-citation>Oh KJ, Kwon BJ, Han MH et al. MR imaging findings of uveal leiomyoma: three cases. AJNR Am J Neuroradiol. 2005 Jan;26(1):100-103.</mixed-citation>
      </ref>
      <ref id="R2431">
        <mixed-citation>Zhou N, Wei W, Xu X. Pathology features and the recults of treatment of two cases of posterior choroidal leiomyoma. BMC Ophthalmol. 2020 Dec;20(1):198.</mixed-citation>
      </ref>
      <ref id="R2432">
        <mixed-citation>Salmon JF, Kanski JJ. Kanski’s clinical ophthalmology: a systematic approach. 9th edition. Erscheinungsort nicht ermittelbar: Elsevier; 2020. p.941.</mixed-citation>
      </ref>
      <ref id="R2433">
        <mixed-citation>Kadaika A, Zhang J, Yao X, Zhou Q, Heiferman MJ. Ultrasound in ocular oncology: Technical advances, clinical applications, and limitations. Exp Biol Med. 2023 May 22;248(5):371-379.</mixed-citation>
      </ref>
      <ref id="R2434">
        <mixed-citation>Foti PV, Travali M, Farina R, et al. Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging-Part I: MR imaging with pathologic correlation and technical considerations. Insights Imaging. 2021 Jun 3;12(1):66.</mixed-citation>
      </ref>
      <ref id="R2435">
        <mixed-citation>Medina CA, Plesec T, Singh AD. Optical coherence tomography imaging of ocular and periocular tumours. Br J ophthalmol. 2014 Jul 1;98(Suppl 2):ii40-46.</mixed-citation>
      </ref>
      <ref id="R2436">
        <mixed-citation>Kuchynka P. Oční lékařství. 2.vyd. Praha:Grada;2016.936. Czech.</mixed-citation>
      </ref>
      <ref id="R2437">
        <mixed-citation>Rusňák Š, Hecová L, Kasl Z, Sobotová M, Hauer L. Uveal Melanoma Biopsy. A review. Cesk Slov Oftalmol. 2020 Aug 30;76(6):247- 252.</mixed-citation>
      </ref>
      <ref id="R2438">
        <mixed-citation>Frizziero L, Midena E, Trainiti S, et al. Uveal Melanoma Biopsy: A Re- CZECH AND SLOVAK OPTHALMOLOGY 5/2024 278 view. Cancers. 2019 Jul 30;11(8):1075.</mixed-citation>
      </ref>
      <ref id="R2439">
        <mixed-citation>Singh AD, Biscotti CV. Fine needle aspiration biopsy of ophthalmic tumors. Saudi J Ophthalmol. 2012 Apr 1;26(2):117-123.</mixed-citation>
      </ref>
      <ref id="R2440">
        <mixed-citation>Solnik M, Paduszyńska N, Czarnecka AM, et al. Imaging of Uveal Melanoma-Current Standard and Methods in Development. Cancers. 2022 Jan;14(13):3147.</mixed-citation>
      </ref>
      <ref id="R2441">
        <mixed-citation>Foti PV, Travali M, Farina R, et al. Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging-Part II: treatment indications and complications, Insights Imaging. 2021 Jun 4;12(1):67.</mixed-citation>
      </ref>
      <ref id="R2442">
        <mixed-citation>Rusňák Š, Hecová L, Kasl Z, Sobotová M, Hauer L, Therapy of Uveal Melanoma. A Review. Cesk Slov Oftalmol. 2021 Aug 30;77(1):1-13.</mixed-citation>
      </ref>
      <ref id="R2443">
        <mixed-citation>Grossniklaus HE, Eberhart CG, Kivelä TT. WHO classification of tumours of the eye. 4th ed. Lyon: International agency for research on cancer;2018. (Worlh health organization classification of tumours).</mixed-citation>
      </ref>
      <ref id="R2444">
        <mixed-citation>Konstantinidis L, Damato B. Intraocular Metastases-A Review. Asia- -Pac J Ophthalmol. 2017 Apr;6(2):208.</mixed-citation>
      </ref>
      <ref id="R2445">
        <mixed-citation>Jindal A, Kapatia G, Gupta G. Ocular metastasis from renal malignacies - A comprehensive review. Indian J Ophthalmol. 2023 Oct;71(10):3281.</mixed-citation>
      </ref>
      <ref id="R2446">
        <mixed-citation>Yu Y, Cheng Y, Wang K, Sun K, Shen D, Liang J. Intraocular schwannoma: A case series of 3 patients. Oncol Lett. 2019 Jan;17(1):1274-1278.</mixed-citation>
      </ref>
      <ref id="R2447">
        <mixed-citation>Reidy JJ, Apple DJ, Steinmetz RL, et al. Melanocytoma: nomenclature, pathogenesis, natural history and treatment. Surv Ophthalmol. 1985;29(5):319-327.</mixed-citation>
      </ref>
      <ref id="R2448">
        <mixed-citation>Shields JA, Demirci H, Mashayekhi A, Eagle RC, Shields CL. Melanocytoma of the optic disk: A review. Indian J Ophthalmol. 2019 Dec;67(12):1949-1958.</mixed-citation>
      </ref>
      <ref id="R2449">
        <mixed-citation>Pecorella I, Ciocci L, Modesti M, Appolloni R. Adenoma of the non- -pigmented ciliary epithelium: A rare intraocular tumor with unusual immunohistochemical findings. Pathol - Res Pract. 2009 Dec 15;205(12):870-875.</mixed-citation>
      </ref>
      <ref id="R2450">
        <mixed-citation>Mansoor S, Qureshi A. Ciliary body adenoma of non-pigmented epithelium. J Clin Pathol. 2004. Sep;57(9):997-998.</mixed-citation>
      </ref>
      <ref id="R2451">
        <mixed-citation>Peshtani A, Kaliki S, Eagle RC, Shields CL. Medulloepithelioma: A triad of clinical features. Oman J Ophthalmol. 2014;7(2):93-95.</mixed-citation>
      </ref>
      <ref id="R2452">
        <mixed-citation>https://fyra.io. Retina Today. Bryn Mawr Communications; [cited 2024 March 13]. Choroidal Hemangioma Masquerading as Central Serous Chorioretinopathy. Available from: https://retinatoday. com/articles/2012-apr/choroidal-hemangioma-masquerading- -as-central-serous-chorioretinopathy</mixed-citation>
      </ref>
      <ref id="R2453">
        <mixed-citation>Karimi S, Nourinia R, Mashayekhi A. Circumscribed Choroidal Hemangioma. J Ophthalmic Vis Res. 2015;10(3):320-328.</mixed-citation>
      </ref>
    </ref-list>
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</article>
