<?xml version="1.0" encoding="UTF-8"?>
<article article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Czech and Slovak Ophthalmology</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">375</article-id>
      <article-id pub-id-type="doi">10.31348/2025/29</article-id>
      <article-categories>
        <subj-group>
          <subject>Case report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Subretinal Triamcinolone Acetonide and Transpupillary Thermotherapy in Circumscribed Choroidal Hemangioma. A Case Report</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Umanets</surname>
            <given-names>Mykola</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5533-1956</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Kustryn</surname>
            <given-names>Taras</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Pasyechnikova</surname>
            <given-names>Nataliya</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5718-8700</contrib-id>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>8</day>
        <month>7</month>
        <year>2025</year>
      </pub-date>
      <issue>2</issue>
      <elocation-id>6</elocation-id>
      <abstract>
        <p>Purpose: To evaluate the potential use of a combination of subretinal triamcinolone acetonide (TA) injection with transpupillary thermotherapy (TTT) in the treatment of circumscribed choroidal hemangioma (CCH) with exudative retinal detachment. Case report: The clinical case of a 27-year-old patient demonstrates the treatment of CCH with exudative retinal detachment. We used a combination of subretinal injection of 4 mg preservative-free TA with the simultaneous partial aspiration of subretinal fluid in the first stage. After one week, when the retina was fully attached, TTT of CCH was used in the second stage. At Month 12, visual acuity in the left eye increased from light perception with projection to 20/400. Ultrasonography did not reveal any signs of choroidal masses or retinal detachment. During the follow-up period, 3 sessions of TTT were performed. Conclusion: A combination of subretinal TA injection with TTT can be an alternative treatment for CCH with exudative retinal detachment.</p>
      </abstract>
      <kwd-group>
        <kwd>circumscribed choroidal hemangioma</kwd>
        <kwd>exudative retinal detachment</kwd>
        <kwd>subretinal injection</kwd>
        <kwd>triamcinolone acetonide</kwd>
        <kwd>transpupillary thermotherapy</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
      <title>References</title>
      <ref id="R2">
        <mixed-citation>Singh AD, Kaiser PK, Sears JE. Choroidal hemangioma. Ophthalmol Clin North Am. 2005;18(1):151-161.</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Shields CL, Dalvin LA, Lim LS, et al. Circumscribed Choroidal Hemangioma: Visual Outcome in the Pre-Photodynamic Therapy Era versus Photodynamic Therapy Era in 458 Cases. Ophthalmol Retina.2020;4(1):100-110.</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Korol A, Nasinnyk I. Retina Lasers in Ophthalmology In: Grzybowski, A., Luttrull, J.K., Kozak, I. (eds). Springer, Cham; c2023. Chapter 8, Laser Treatment in Intraocular Tumors; p. 183-194.</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Hsu CC, Yang CS, Peng CH, Lee FL, Lee SM. Combination photodynamic therapy and intravitreal bevacizumab used to treat circumscribed choroidal hemangioma. J Chin Med Assoc. 2011;74(10):473-477.</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>Bazin L, Gambrelle J. Traitement combiné par photothérapie dynamique et implant intravitréen de dexaméthasone (Ozurdex(®)) pour un hémangiome choroïdien circonscrit [Combined treatment with photodynamic therapy and intravitreal dexamethasone implant (Ozurdex(®)) for circumscribed choroidal hemangioma]. J Fr Ophtalmol. 2012;35(10):798-802. French.</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Blasi MA, Tiberti AC, Scupola A, et al. Photodynamic therapy with verteporfin for symptomatic circumscribed choroidal hemangioma: five-year outcomes. Ophthalmology. 2010; 117(8):1630-1637.</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Sirks MJ, van Dijk EHC, Rosenberg N, et al. Clinical impact of the worldwide shortage of verteporfin (Visudyne®) on ophthalmic care. Acta Ophthalmol. 2022;100(7):e1522-e1532.</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Tsukanova IV, Poliakova SI, Naumenko VO, et al. Efficacy of 810- nm diode laser transpupillary thermotherapy delivered using the methodology developed for small (T1) choroidal melanomas. J ophthalmol (Ukraine). 2019;3:36-40.</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Gunduz K. Transpupillary thermotherapy in the managementof circumscribed choroidal hemangioma. Surv Ophthalmol. 2004;49:316-326.</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Wang YS, Friedrichs U, Eichler W, Hoffmann S, Wiedemann P. Inhibitory effects of triamcinolone acetonide on bFGF-induced migration and tube formation in choroidal microvascular endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2002;240:42-48.</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Parrozzani R, Pilotto E, Dario A, Miglionico G, Midena E. Intravitreal triamcinolone versus intravitreal bevacizumab in the treatment of exudative retinal detachment secondary to posterior uveal melanoma. Am J Ophthalmol. 2013;155(1):127-133.</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Tao Y, Jonas JB. Intravitreal triamcinolone. Ophthalmologica. 2011;225(1):1-20.</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Kustryn T, Nasinnyk I, Nevskaya A, Zadorozhnyy O, Korol A. Changes in structural and functional retinal features resulting from the effect of a long-acting steroid in serous PED associated with AMD: a 36-month follow-up study. J ophthalmol (Ukraine). 2016;5:28- 34.</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Ejstrup R, la Cour M, Heegaard S, Kiilgaard JF. Toxicity profiles of subretinal indocyanine green, Brilliant Blue G, and triamcinolone acetonide: a comparative study. Graefes Arch Clin Exp Ophthalmol. 2012;250(5):669-677.</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Kozak I, Cheng L, Falkenstein I, Tammewar AM, Freeman WR. Evaluation of subretinal triamcinolone acetonide in patients with exudative age-related macular degeneration. J Ocul Pharmacol Ther. 2007;23(1):46-53.</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Aizman A, Finger PT, Shabto U, et al. Palladium 103 (103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment. Arch Ophthalmol. 2004;122: 1652-1656.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
