2016 - 1 Issue

Original article

Perspects of the Cell Therapy in Ophthalmology. 2. The Potential of Stem Cells of Retinal Diseases Treatment

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Summary

Retinal diseases represent a large group of hereditary and acquired diseases that often lead to loss of vision. There is currently no effective treatment of retinal degeneration, only supportive therapy is used for treating numerous diseases. Perspective treatment of retinal diseases represent a cell therapy using stem cells. Suitable candidates for the stem cell therapy are mesenchymal stem cells due to their differentiating properties, protective effect and also immunomodulation.

References

  1. Alonso-Alonso, M. L., Srivastava, G. K.: Current focus of stem cell application in retinal repair. World J Stem Cells, 7; 2015: 641–648.
  2. Arnhold, S., Absenger, Y., Klein, H. et al.: Transplantation of bone marrowderived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse. Graefe’s Arch Clin Exp Ophthalmol, 245; 2007: 414–422.
  3. Bull, N. D., Martin, K. R.: Concise Review: Toward Stem Cell‐Based Therapies for Retinal Neurodegenerative Diseases. Stem Cells, 29; 2011: 1170–1175.
  4. Garcia, J.M., Mendonça, L., Brant, R. et al.: Stem cell therapy for retinal diseases. World J Stem Cells, 7; 2015: 160–164.
  5. Guan, Y., Cui, L., Qu, Z. et al.: Subretinal transplantation of rat MSCs and erythropoietin gene modified rat MSCs for protecting and rescuing degenerative retina in rats. Curr Mol Med, 13; 2013: 1419–1431.
  6. Hermankova, B., Zajicova, A., Javorkova, E. et al.: Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-γ-treated mesenchymal stem cells. Immunobiology, 221; 2016: 129-36..
  7. Holan, V., Javorkova, E.: Mesenchymal stem cells, nanofiber scaffolds and ocular surface reconstruction. Stem Cell Rev, 9; 2013: 609–619.
  8. Huang, C., Zhang, J., Ao, M. et al.: Combination of retinal pigment epithelium cell‐conditioned medium and photoreceptor outer segments stimulate mesenchymal stem cell differentiation toward a functional retinal pigment epithelium cell phenotype. J Cell Biochem, 113; 2012: 590–598.
  9. Huo, D.M., Dong, F.T., Yu, W.H. et al.: Differentiation of mesenchymal stem cell in the microenvironment of retinitis pigmentosa. Int J Ophthalmol, 3; 2010: 216–219. junctiva mesenchymal stem cells on nanofibrous scaffolds. Mol Biol Rep, 40; 2013: 3883–3890.
  10. Chiou, S.H., Kao, C.L., Peng, C.H. et al.: A novel in vitro retinal differentiation model by co-culturing adult human bone marrow stem cells with retinal pigmented epithelium cells. Biochem Biophys Res Commun, 326; 2005: 578– 585.
  11. Javorkova, E., Trosan, P., Zajicova, A. et al.: Modulation of the early inflammatory microenvironment in the alkali-burned eye by systemically administered interferon-gamma-treated mesenchymal stromal cells. Stem Cells Dev, 23; 2014: 2490–2500.
  12. Johnson, T.V., Bull, N.D., Hunt, D.P. et al.: Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest Ophthalmol Vis Sci, 51; 2010: 2051– 2059.
  13. Johnson, T.V., Bull, N.D., Martin, K.R.: Neurotrophic factor delivery as a protective treatment for glaucoma. Exp Eye Res, 93; 2011: 196–203.
  14. Kicic, A., Shen, W.Y., Wilson, A.S., Constable, I.J., Robertson, T., Rakoczy, P.E.: Differentiation of marrow stromal cells into photoreceptors in the rat eye. J Neurosci, 23; 2003: 7742–7749.
  15. Krampera, M., Pasini, A., Pizzolo, G. et al.: Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin Pharmacol, 6; 2006: 435–441.
  16. Mathivanan, I., Trepp, C., Brunold, C. et al.: Retinal differentiation of human bone marrow-derived stem cells by coculture with retinal pigment epithelium in vitro. Exp Cell Res, 333; 2015: 11–20.
  17. Meisel, R., Zibert, A., Laryea, M. et al.: Human bone marrow stromal cells inhibit allogenetic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood, 103; 2004: 4619–4621.
  18. Nadri, S., Kazemi, B., Eslaminejad, M.B. et al.: High yield of cells committed to the photoreceptor-like cells from con-
  19. Ng, T.K., Fortino, V.R., Pelaez, D. et al.: Progress of mesenchymal stem cell therapy for neural and retinal diseases. World J Stem Cells, 6; 2014: 111–119.
  20. Rajashekhar, G., Ramadan, A., Abburi, C. et al.: Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PloS One, 9; 2014.
  21. Rowland, T.J., Buchholz, D.E., Clegg, D.O.: Pluripotent human stem cells for the treatment of retinal disease. J Cell Physiol, 227; 2012: 457–466.
  22. Sato, K., Ozaki, K., Oh, I. et al.: Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood, 10; 2007: 228–234.
  23. Svobodova, E., Krulova, M., Zajicova, A. et al.: The role of mouse mesenchymal stem cells in differentiation of naive Tcells into anti-inflammatory regulatory T-cell or proinflammatory helper T-cell 17 population. Stem Cells Dev, 21; 2011: 901–910.
  24. Vossmerbaeumer, U., Ohnesorge, S., Kuehl, S. et al.: Retinal pigment epithelial phenotype induced in human adipose tissue-derived mesenchymal stromal cells. Cytotherapy, 11; 2009: 177–188.
  25. Yang, Z., Li, K., Yan, X. et al.: Amelioration of diabetic retinopathy by engrafted human adipose-derived mesenchymal stem cells in streptozotocin diabetic rats. Graefe’s Arch Clin Exp Ophthalmol, 248; 2010: 1415–1422.
  26. Yu, S., Tanabe, T., Dezawa, M. et al.: Effects of bone marrow stromal cell injection in an experimental glaucoma model. Biochem Biophys Res Commun, 344; 2006: 1071–1079.
  27. Zhang, Y., Wang, W.: Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retina. Invest Ophthalmol Vis Sci, 51; 2010: 3742–3748.